Too many Western policymakers in the United States and across the European Union still remain attached to an “end of history” worldview, which has somewhat blinded them to the resurgence of great power politics. For the past decade or so, the unipolar world has been breaking apart due to various centrifugal geopolitical trends. The COVID-19 pandemic did not cause these trends, but is accelerating them. A leaderless, multipolar world on the cusp of de-globalization and the onset of a cold war between the United States and the People’s Republic of China is a recipe for skyrocketing unpredictability and increased instability. This article traces the origins of these trends and provides a framework to analyze the political trajectories and geopolitical (and ethical) consequences thereof.