A change in U.S. administrations can often result in significant policy shifts. However, in the case of South Asia, with marked exceptions, U.S. policy has been mostly consistent. That said, the new administration will confront important challenges at global, regional, and bilateral levels that involve South Asia. To that end, the administration will have to deal with questions of climate change, global trade, and transnational terror. It will also have to confront the nettlesome question of the future of Afghanistan as well as the growing religious intolerance and conflict in the overall region. Finally, given India’s significance to the region and beyond, it will need to devise policies designed to place the bilateral relationship on a more secure footing.