To form a more prudent foreign policy toward the Muslim Brotherhood, we must understand it not only as a domestic actor, but also as a major regional player. In fact, the Brotherhood has a complex relationship with Iran and the Shias, which blurs the lines of the so-called Shia Crescent. This article addresses the Muslim Brotherhood’s foreign/regional policy by analyzing its attitude toward the Shias and Iran, thus placing it within the context of the emerging regional order. Addressing the complex relationship between the Muslim Brotherhood and the Shias/Iran will help to clarify the regional fallout were the Brotherhood to gain control of a major Sunni Arab state. This is a vital issue for policy makers who are considering the U.S. position vis-à-vis the Brotherhood.